Parkinson disease is progressive neurodegenerative disease occurs due to several causative factor although dopamine deficiency is prime characteristic of the disease. Environmental toxin, genetic abnormalities, drugs, oxidative stress are some of causative factor responsible development of parkinson disease. Currently available drugs for the treatment of this disorder are able to provide only symptomatic relief. Moreover their use is associated with lot of adverse effects. The importance of medicinal plants comes in this context. In present study haloperidol was used to induce the Parkinsons like symptoms in wistar albino rats. Hydro-alcoholic extracts of Parkinsonia aculeate L. seeds at the dose (200mg/kg) was administered orally. After one hour haloperidol (1 mg/kg p.o.) was administered. Catalepsy score was recorded at interval of one hour. The results indicate that administration of haloperidol significantly induced the catalepsy in wistar albino rats, which was significantly reversed by administration of hydroalcoholic extract of Parkinsonia aculeata L. Seeds. (P<0.05) and Ananas cosmosus L.
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